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Targeted Nutrition Acts on Underlying Mechanisms of Peripheral Neuropathy

While many current peripheral neuropathy treatments focus on symptom management, targeted nutrition from Metanx® acts on the root causes of PN. Continued use of Metanx can lead to nerve repair, improved nerve function, and reduced pain and discomfort.

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MetanxPRO Nerve Health™ bottle with 180 capsules

Why Consider Metanx®?

Metanx® and its nutrients have been shown in several studies† to help:

Repair nerve structure
Restore nerve function & sensation
Protect against further nerve damage
Reduce nerve discomfort like pain and pins & needles
View Clinical Data

How Bioactive Nutrients Affect PN Symptoms & Progression

Several studies have noted how appropriate nutrition is important in maintaining peripheral nerve health and supporting nerve regeneration. Deficiencies in certain nutrients have been seen to contribute to PN progression.
Diagram of nerve repair with structure, signaling, and energy components.
methylation regulation icon Methylation Regulation
Impaired one-carbon metabolism may disrupt neurotransmitter synthesis, elevate homocysteine,54 and reduce neurotrophic signaling needed for nerve repair.55
endothelial function icon Endothelial Function
Nitric oxide imbalance and elevated homocysteine may compromise endothelial integrity, reducing nutrient delivery to nerve tissue.56
oxidative stress and inflammation icon Oxidative stress & inflammation
Excess reactive oxygen species and chronic inflammation may damage nerve membranes and accelerate neurodegeneration. 57,58
mitochondrial function icon Mitochondrial Function
Reduced ATP production and mitochondrial stress can limit axonal transport,59 impair nerve regeneration,28 and disrupt cellular energy homeostasis.60
microvascular perfusion icon Microvascular Perfusion
Impaired blood flow and oxygenation can lead to ischemic stress61 and further nerve tissue damage.10

Metanx® Nutrients & Key Biological Pathways They Affect

L-methylfolate/folate

7x more bioactive form of folate than in folic acid supplements. Supports vascular health and neurotransmitter synthesis to aid nerve repair.9,21,35

Pyridoxal 5'-phosphate

A bioactive coenzyme form of vitamin B6 that supports neurotransmitter balance, helps reduce oxidative stress and helps restore nerve signaling.21,39,40

Methylcobalamin

Bioactive form of vitamin B12 that supports nerve structure by promoting myelin regeneration and reducing oxidative stress.15,31

Acetyl-L-carnitine

A conditionally essential nutrient that helps restore mitochondrial energy production and modulate pain response.16,17,30

MetanxPRO Nerve Health™only