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Metanx® is a medical food, sold by prescription, designed to meet the nutritional needs of people with peripheral neuropathy (PN). It contains key nutrients that act on nutrient deficiencies associated with PN to support nerve repair and help improve peripheral neuropathy symptoms.

If you have peripheral neuropathy symptoms or have been diagnosed with peripheral neuropathy or diabetic peripheral neuropathy, talk to your doctor to see if Metanx® is a good fit for your care plan.

Each capsule contains 3mg of L-Methylfolate Calcium (as Metafolin®), 35mg of Pyridoxal-5-Phosphate and 2mg of Methylcobalamin.

Metanx FC™ contains: Microcrystalline Cellulose and Silicon Dioxide, Vegetarian Capsule (Hypromellose, Carrageenan, Potassium Acetate, Black Iron Oxide, Hydroxypropyl Cellulose), Pyridoxal-5-Phosphate, L-Methylfolate Calcium, Methylcobalamin, Magnesium Stearate.

Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.

Each capsule contains 3mg of L-Methylfolate Calcium (as Metafolin®), 35mg of Pyridoxal-5-Phosphate, 2mg of Methylcobalamin and 500mg of Acetyl-L-Carnitine.

MetanxPRO Nerve Health™ contains: Acetyl-L-Carnitine HCl, Vegetarian Capsule (Hypromellose, Black Iron Oxide), Microcrystalline Cellulose, Pyridoxal-5-Phosphate (Vitamin B6), Silicon Dioxide, Magnesium Stearate (Vegetable Source), L-Methylfolate Calcium, Methylcobalamin (Vitamin B12).

Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.

Bioactive nutrients are nutrients that are more easily absorbed by the body than many nutrients you get through diet or supplementation. For example, folic acid and folate are found in foods and many over-the-counter supplements, but they need to be broken down by the body first before your body can use them. The ingredients in Metanx® are already in their bioactive forms so your body can use them right away.

Metanx FC™ and MetanxPRO Nerve Health™ are manufactured and distributed by: Alfasigma USA, Inc. Shreveport, LA 71103.

The bioactive ingredients in Metanx® help address nutrient deficiencies that may cause peripheral neuropathy. These factors include blood flow problems, nutritional deficiencies, nerve damage, and stress and inflammation. By doing this, these nutrients support nerve repair, which can then result in restored nerve function and improved peripheral neuropathy symptoms.

Bioactive nutrients can be absorbed and used by the body efficiently, while folate and other nutrients found in supplements need to be broken down by the body first before you can absorb the nutrition. For example, L-methylfolate (found in Metanx®) provides up to 7 times greater bioavailability vs. folic acid supplements. To get the same nutritional value of one MetanxPRO Nerve Health™ capsule, you would need to take 21 folic acid tablets (1mg each), 2 tablets of 1mg vitamin B12, 2 tablets of 25mg vitamin B6, and 1 tablet of 500mg acetyl-L-carnitine. For additional reference, the typical Metanx® dose required is 2 tablets per day.^5,48,49

The nutrients themselves don’t repair damaged nerves, but the ingredients collectively help address nutritional deficiencies, blood flow problems, stress and inflammation that can cause nerve damage. This then enables the nerve to repair and helps increase nerve density to restore nerve function and reduce peripheral neuropathy symptoms.

Metanx® is offered by prescription for use under medical supervision for the clinical dietary management of peripheral neuropathy.

Metanx® can be used safely along with diabetic peripheral neuropathy and diabetes medications, as well as many other medications. Talk to your doctor about the medications you are taking.^6,7

Taking MetanxPRO Nerve Health™ may be associated with less burning and deep-aching pain in as little as 2 weeks, based on clinical studies on acetyl-L-carnitine (ALC). With Metanx FC™, you may start to feel signs of improvement within 12 weeks. Keep in mind that damaged nerves need time to repair and individual results may vary.^1-5

In clinical studies, Metanx®† was shown to have side effects similar to a placebo.⁶

When your doctor prescribes Metanx® through Brand Direct Health® Pharmacy, you pay an everyday low price and have a money-back guarantee. You can take advantage of flexible payment options for a 90-day prescription or use your FSA or HSA to pay.

The ingredients in Metanx® have been clinically studied† and shown to support the repair of nerves in patients with diabetic peripheral neuropathy (the most common form of PN).⁷ They’ve also been shown to address the multiple factors that may cause similar forms of peripheral neuropathy, such as nerve damage associated with alcohol consumption, chemotherapy, and HIV.^50-53

Peripheral neuropathy can have many causes including infections, chronic diseases, injuries, toxins and certain medications. Typically, these factors can cause problems with blood flow, stress and inflammation, nutritional deficiencies and nerve damage.

Yes, typically peripheral nerves that are damaged can regenerate and function can be restored. However, this process can take time and may not always lead to complete recovery. As nerves repair and grow, nerve function is restored and many of the peripheral neuropathy symptoms will improve.

Many vitamins and other nutrients are thought to support peripheral nerve health. Four that have been clinically studied and shown to support nerve health and nerve repair are: L-Methylfolate Calcium, Methylcobalamin (Vitamin B12), Pyridoxal-5’-Phosphate (Vitamin B6), and Acetyl-L-Carnitine, the ingredients in MetanxPRO Nerve Health™.